Endothelial Dysfunction for Prognosis In Patients With preeClampSia
Recruiting now
Conditions studied: Preeclampsia (PE), Hypertensive Disorder of Pregnancy
In brief
Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus. Endothelial and microcirculatory dysfunction mediate systemic preeclampsia-related organ dysfunctions. Changes in endothelial and vascular function in preeclampsia have been demonstrated through reduced flow-mediated vasodilation as a result of reduced availability of nitric oxide, which potentially persists up to several years postpartum. Hyperspectral imaging is a new innovative technology that allows to assess the peripheral microcirculation and perfusion non-invasively and contactless, but has never been evaluated in the context of preeclampsia before. This EPICS project (Endothelial dysfunction for Prognosis In patients with preeClampSia) is a prospective observational study and aims to investigate hyperspectral imaging as a new potential diagnostic and prognostic marker in preeclampsia.
Key facts
- Study ID
- NCT06912477
- Run by
- Heidelberg University
- People needed
- 385
- Starts
- 2025-05-08
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2025-05-11
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- singleton pregnancies
- Age ≥ 18 years
- Patient's ability to provide consent
- written informed consent
You may not qualify if…
- Lack of consent
- Language barrier
- Dark to very dark skin type
- Severe fetal chromosomal/genetic/structural anomalies
- Laboratory changes in LDH, creatinine, or platelets due to other causes (e.g., isolated thrombocytopenia, e.g., immune thrombocytopenia, carcinoma)
Where it is running
- Heidelberg University Hospital, Department of Gynecology and Obstetrics — Heidelberg, Germany (enrolling)
Full record on ClinicalTrials.gov
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