Continous Positive Airway Pressure (CPAP) Support for Acute Hypoxemic Respiratory Failure in Burkina Faso

Recruiting now · Not applicable

Conditions studied: Acute Respiratory Failure

In brief

Acute respiratory failure (ARF) is a frequent medical emergency, involving high costs for health organizations and patients who often require intensive care and respiratory assistance. According to an international study, 61% of hypoxemic patients in intensive care receive invasive ventilation \[3\]. Invasive mechanical ventilation is often unavailable in low-income countries and non-invasive ventilatory supports such as continuous positive airway pressure (CPAP) and high-flow oxygen therapy (HFO) were very useful during the COVID-19 pandemic. They reduced the rate of intubation and ICU admissions. In addition, CPAP can be used without a ventilator, no electricity is required. So, it could be a support of choice in low-income countries. Used of Boussignac-type CPAP could potentially reduce the recourse to intubation in patients with acute hypoxemic respiratory failure in a context where access to invasive ventilation remains very limited.

Key facts

Study ID: NCT06912360
Run by: Université NAZI BONI
People needed: 240
Starts: 2025-07-09
Expected to finish: 2026-02-20
Last updated by the study team: 2025-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

All patients aged 18 years and older will be included in the study if they meet at least one of the following criteria :
Acute respiratory distress, defined as dyspnea respiratory rate ≥ 25 cycles/min
Hypoxemia, defined as the need for more 6 liters of oxygen to maintain an oxygen saturation (SpO2) of ≥ 92%. The fraction of inspired oxygen (FiO2) will be estimated using the 3% rule.

You may not qualify if…

Patients with any of the following criteria will not be included in the study:
Pregnant or breastfeeding women
Persons deprived of their liberty
Exacerbation of asthma, chronic obstructive pulmonary disease, or another chronic respiratory disease
Moderate to large amount of unilateral or bilateral undrained pleural effusion
Contraindication to CPAP: patient refusal, undrained pneumothorax, chest injury, repeated or large vomiting, upper gastrointestinal bleeding, craniofacial trauma, severe upper airway obstruction, or tetraplegia in the initial phase
Cardiac arrest, severe arrhythmias, shock requiring the use of vasopressors (norepinephrine, adrenaline, dopamine)
Altered level of consciousness (Glasgow Coma Scale score < 13), repeated seizures, or status epilepticus
Medical decision to limit treatment: no intubation, no admission to intensive care
Refusal to participate in the study or participation in another interventional study on respiratory distress or acute respiratory failure.

Where it is running

Centre Hospitalier Universitaire Souro Sanou — Bobo-Dioulasso, Houet, Burkina Faso (enrolling)
CHU Yalgado Ouedraogo — Ouagadougou, Kadiogo, Burkina Faso
CHU Tengandogo — Ouagadougou, Kadiogo, Burkina Faso
CHU Bogodogo — Ouagadougou, Kadiogo, Burkina Faso

Full record on ClinicalTrials.gov

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