Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
Recruiting now
Conditions studied: Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
In brief
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.
Key facts
- Study ID
- NCT06912321
- Run by
- Nanjing First Hospital, Nanjing Medical University
- People needed
- 400
- Starts
- 2024-05-01
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2025-04-04
Who can join
Age: 45 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- T2DM patients met the diagnostic criteria for diabetes (WHO, 1999) with a duration of 3-20 years; The control group met the criteria of fasting blood glucose < 6.1mmol/l and glycosylated hemoglobin < 5.7%;
- right-handed, aged 45-70 years, with ≥8 years of education;
- no contraindications to MRI scanning such as electronic and metal device implantation;
- The visual acuity or corrected visual acuity and binaural hearing can meet the needs of the evaluation, and can cooperate to complete the examination.
- without a history of substance abuse or dependence, evaluation is not used during the period of calm sleeping pills and antidepressants, not long-term use of drugs to improve cognitive.
You may not qualify if…
- patients with acute metabolic complications or a history of severe hypoglycemia;
- severe heart, liver, lung, kidney and hematopoietic system diseases; Hyperthyroidism or hypothyroidism; Stroke, alzheimer's disease, epilepsy, Parkinson's disease and other neurological history; A history of mental illness such as depression, mania, or alcohol dependence; History of loss of consciousness due to neurological diseases or traumatic brain injury;
- one month before the laboratory examination, with a record and surgical trauma infection;
Where it is running
- Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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