Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Recruiting now · Not applicable

Conditions studied: Parkinson Disease

In brief

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Key facts

Study ID

NCT06911229

Run by

University of Florida

People needed

60

Starts

2025-10-01

Expected to finish

2027-07-31

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
• chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
• Age between 18 - 80 years old per the FDA data sheet for PD DBS;
• no dementia according to the clinical diagnostic criteria for PD dementia;
• ambulatory without the use of walking aids, or another person's assistance.

You may not qualify if…

• other previous neurological surgery;
• suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Where it is running

• University of Florida — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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