Yeast Mannans and Stool Frequency
Running, not enrolling · Not applicable · Has a placebo group
Conditions studied: Defecation Frequency
In brief
Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Secondary aims will determine the effect of yeast mannans on intestinal transit time, gastrointestinal symptoms, fecal microbiota composition, and urinary and fecal metabolomics.
Key facts
- Study ID
- NCT06911177
- Run by
- University of Florida
- People needed
- 70
- Starts
- 2025-07-17
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults who report a stool frequency of ≤ 1 per day.
- Able to provide written informed consent in English.
- Willingness to consume 1 supplement (12 g of yeast mannans or control) daily for 28 days.
- Willingness to maintain their usual diet and physical activity patterns throughout the study and refrain from the consumption of any yeast-based foods (e.g. Marmite or Vegemite) or yeast extract supplements.
- Willing to comply with study procedures, including stool and urine colle
You may not qualify if…
- Stool frequency of < 3 per week
- Yeast allergy
- Vegan dietary pattern
- Self-reported kidney disease
- Elite athletes or long-distance runners
- Use of antibiotic drugs within 1 month of screening
- Current use of laxatives or antidiarrheal medications
- Use of other investigational products within 3 months of the screening
- Previously or currently being treated for intestinal diseases or conditions, including irritable bowel disease (i.e., IBS-D or IBS-mixed), Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal cancer.
- Previous gastrointestinal surgery (e.g., gastric bypass, fundoplication, bowel resection).
- Current cancer treatment.
- Currently pregnant.
Where it is running
- Department of Food Science and Human Nutrition — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.