Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

Recruiting now · Not applicable

Conditions studied: Bone Marrow Transplant Complications, Graft-versus-Host Disease

In brief

The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.

Key facts

Study ID

NCT06910969

Run by

Massachusetts General Hospital

People needed

350

Starts

2025-08-13

Expected to finish

2030-02-01

Last updated by the study team

2026-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥ 18 years) who have undergone allogeneic HCT
• Have moderate to severe cGVHD based on patient-report
• Have ability to participate in English or Spanish language group telehealth intervention.

You may not qualify if…

• Patients with mild cGVHD based on their self-report.
• Patients with a major untreated psychiatric or cognitive condition which the treating oncology clinicians believes interferes with the capacity to provide informed consent.
• Patients with active relapsed disease requiring therapy.

Where it is running

• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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