IDOV-Immune for Advanced Solid Tumors
Recruiting now · Phase 1
Conditions studied: Colorectal Cancer, Pancreatic Cancer, Melanoma, Ovarian Cancer, Gastric Cancer, Esophageal Cancer, Hepatocellular Carcinoma, Renal Cell Carcinoma, Breast Cancer, Sarcoma, Bladder Cancer, Lung Cancer, Prostate Cancer, Cervical Cancers, Head and Neck Cancers, Adrenal Gland Tumors
In brief
This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cells and have the potential to stimulate the immune system to fight the tumor. The purpose of this study is to determine the safety of IDOV-Immune, how well it is tolerated, and to identify the highest dose that can be safely given. Researchers will also study how the drug behaves in the body, how the immune system responds to it, and whether it shows any signs of shrinking tumors. Participants will receive a single intravenous (IV) infusion of IDOV-Immune and will be closely monitored for side effects and any changes in their cancer. This study is being conducted at multiple sites in the United States and Australia.
Key facts
- Study ID
- NCT06910657
- Run by
- ViroMissile, Inc.
- People needed
- 78
- Starts
- 2025-08-25
- Expected to finish
- 2027-05-31
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
- MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- South Texas Accelerated Research Therapeutics — San Antonio, Texas, United States (enrolling)
- Westmead Hospital — Westmead, New South Wales, Australia (enrolling)
- The Alfred Hospital — Melbourne, Victoria, Australia (enrolling)
Full record on ClinicalTrials.gov
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