Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers

Recruiting now · Phase 2/Phase 3

Conditions studied: Aphthus Ulcer

In brief

Interventions of both groups: Oxygenated gel Group: 15 patients who used oxygenated gel (Blue®m, Wijhe, Netherlands) were trained by the co-investigator (A.H) through real demonstration for topical application of the gel on aphthous ulcers, which entails the application of 1-2 ml of oxygenated gel directly to the ulcer two times per day and this was repeated for 7 days. Triamcinolone acetonide Group: 15 patients were treated with Kenalog in orabase (Triamcinolone acetonide 0.1% oral paste 5g), four times (i.e., at 8 am, 12 noon, 4 pm, and 8 pm) a day for 7 days at intervention group. Patients in both groups were reexamined after treatment at different intervals (day 3, day 5, day 7, and day 10).

Key facts

Study ID

NCT06910579

Run by

British University In Egypt

People needed

30

Starts

2025-03-15

Expected to finish

2026-04-12

Last updated by the study team

2025-09-18

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically diagnosed patients with chronic aphthous stomatitis measuring ≤6 mm in size in the oral cavity and who gave written consent for participation.
• Only single ulcers were considered for the study.
• Systemically healthy patients.

You may not qualify if…

• The study excluded patients with a history of associated systemic disease.
• Cases of chronic aphthous stomatitis (major), lesions of herpetic form, numerous aphthae, and smoking.
• Patients with a history of hypersensitivity to the used agents.
• Pregnancy and lactation

Where it is running

• British University in Egypt — Al Sherouk City, Cairo Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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