Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
Recruiting now
Conditions studied: Esophageal Varices
In brief
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients. Researchers will compare fecal calprotectin levels in cirrhotic patients with and without esophageal varices (EVs) and healthy subjects. researchers will also evaluate the performance of fecal calprotectin, AST to platelet ratio index (APRI) score, fibrosis-4 (FIB-4) score, albumin-bilirubin (ALBI) score, platelet-albumin-bilirubin (PALBI) score, and platelet-spleen diameter ratio (PSR) for predicting esophageal varices. Participants will undergo history-taking, clinical examination, laboratory investigations, fecal calprotectin, abdominal ultrasonography, and upper endoscopy. Endoscopic grading of esophageal varices will be done using Paquet's classification. The APRI, FIB-4, ALBI, PALBI, and PSR scores will be calculated. The performance of fecal calprotectin for predicting EVs will be compared versus other non-invasive scores.
Key facts
- Study ID
- NCT06908798
- Run by
- Tanta University
- People needed
- 156
- Starts
- 2024-12-01
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-04-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥18 years
- Liver cirrhosis
You may not qualify if…
- Patients aged < 18 years.
- Inflammatory bowel disease.
- Infectious gastroenteritis.
- Malignancy.
- Patients on proton pump inhibitors or NSAID.
- Patients with spontaneous bacterial peritonitis.
- Patients with hepatic encephalopathy.
- Unwilling to participate in our study.
Where it is running
- Tanta University Hospitals — Tanta, Gharbyea, Egypt (enrolling)
Full record on ClinicalTrials.gov
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