Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTION Trial! A Retrospective Study on Etiology of Liver Failure and Their Complications

Recruiting now

Conditions studied: Liver Failure, AKI - Acute Kidney Injury

In brief

Study design A retrospective cohort study will be conducted to compare the efficacy and safety of citrate anticoagulation in CRRT among patients with liver failure/dysfunction and severe shock. Objectives 1. Primary Objective: To determine if the etiology of liver failure impacts the incidence of citrate-related complications in patients undergoing CRRT. 2. Secondary Objectives: To compare the efficacy of citrate anticoagulation in terms of renal recovery, filter lifespan, and patient survival between those with liver failure/dysfunction and severe shock.

Key facts

Study ID

NCT06908746

Run by

University Hospital, Antwerp

People needed

100

Starts

2024-09-30

Expected to finish

2025-12-31

Last updated by the study team

2025-04-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Critically ill patients diagnosed with AKI requiring CRRT. Caution Protocol V1.0 24-07-2024
• Documented liver failure or significant liver dysfunction (e.g., elevated liver enzymes, bilirubin levels, or clinical diagnosis of liver failure) and clincal diagnosis of shock (NE of 0.25 μg/kg/min and or association of second vasopressor).
• Age ≥ 18 years.

You may not qualify if…

• NA

Where it is running

• Antwerp University Hospital — Edegem, Antwerp, Belgium (enrolling)

Full record on ClinicalTrials.gov

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