Cognitive Bias Modification for Interpretation (CBM-I) in People With Type 2 Diabetes and Persistent Pain

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Type 2 Diabetes, Persistent Pain

In brief

The goal of this clinical trial is to examine the efficacy of cognitive bias modification for interpretation (CBM-I) in people with Type 2 Diabetes and persistent pain. The main question\[s\] it aims to answer is whether interpretation bias training away from pain improves pain outcomes. Participants in the CBM-I group will complete 4 online training sessions approximately half an hour each. Each session will present participants with ambiguous scenarios which may be pain-related, however the final word of the sentence will resolve the scenario as benign (thus training participants to make benign interpretations). A measure of interpretation bias will be administered following the fourth training session, and pain severity and interference will be measured at baseline, post-training, two week follow up, and three month follow up. The study hypothesises that participants in the CBM-I group will demonstrate a greater reduction in the co-primary outcomes of pain severity and pain interference over time compared to those in the placebo control.

Key facts

Study ID

NCT06908486

Run by

University of Sydney

People needed

319

Starts

2025-04-15

Expected to finish

2025-10-15

Last updated by the study team

2025-06-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Over 18 years of age
• Have a diagnosis of Type 2 diabetes.
• Have persistent pain (pain present on more days than not, for 3 months or longer).
• Score ≥ 3 on average pain severity on the Brief Pain Inventory (BPI).
• Fluent in English
• Have access to internet and ability to use a computer over a three month period.

You may not qualify if…

• Under 18 years of age
• No diagnosis of Type 2 diabetes
• No persistent pain
• Not fluent in English
• No access to internet nor ability to use a computer.

Where it is running

• University of Sydney — Camperdown, New South Wales, Australia (enrolling)

Full record on ClinicalTrials.gov

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