Study of Lipid Mediators in Chronic Postoperative Pain - LICP

Recruiting now · Not applicable

Conditions studied: Breast Cancer Female, Postoperative Pain

In brief

This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain. Secondly, it aims to investigate the activation of peripheral blood mononuclear cells and neutrophils in patient blood samples. The study will enrol women aged 18 years or older who have been newly diagnosed with primary invasive or non-invasive breast cancer requiring surgical removal of the tumour, with or without axillary surgery. The main objectives of the study are To assess whether there is an association between circulating levels of lipid mediators and chronicity (\> 3 months) of postoperative pain after breast cancer surgery. To assess whether circulating levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery. To assess the existence of an association between resected tissue levels of lipid mediators and chronicity of postoperative pain in breast cancer surgery. To assess whether tissue levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery.

Key facts

Study ID

NCT06907810

Run by

Université Catholique de Louvain

People needed

300

Starts

2025-03-12

Expected to finish

2027-03-31

Last updated by the study team

2025-04-02

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women older than 18 years
• Newly diagnosed primary invasive or non-invasive breast cancer, requiring surgical excision of the tumor, with or without axillary surgery
• Able to give informed consent

You may not qualify if…

• Men
• Women aged less than 18 years
• Pregnant women
• History of major psychiatric disorders
• Previous breast or axillary surgery, recurrent disease or detectable metastatic disease at the time of diagnosis
• Unable to give informed consent

Where it is running

• Cliniques universitaires Saint-Luc (UCLouvain) — Brussels, Brussels Capital, Belgium (enrolling)

Full record on ClinicalTrials.gov

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