Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)
Recruiting now · Not applicable
Conditions studied: Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
In brief
IRIS-CKD is a two-program implementation study to improve guideline-recommended screening and treatment of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
Key facts
- Study ID
- NCT06906640
- Run by
- Duke University
- People needed
- 420
- Starts
- 2025-10-28
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- (CKD Management)
- Adults with type 2 diabetes (T2D)
- Receiving primary care within the healthcare system, visit within 24 months (any PCP provider, including APP)
- Evidence of CKD based on laboratory testing within the past 2 years (must be confirmed during screening if not checked within 3 months of enrollment):
- UACR >300 mg/g or
- eGFR <45 ml/min/1.73 m2 or
- UACR ≥30 mg/g with eGFR <60 ml/min/1.73 m2
- Receiving <100% GDMT at baseline. For patients with UACR <30 mg/g, GDMT includes sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy. For all other eligible patients, GDMT includes ACEi/ARB, SGLT2i, and Finerenone, unless contraindications for any of these therapies exist (e.g., hyperkalemia, diabetic ketoacidosis, etc.).
You may not qualify if…
- (CKD Management)
- Type 1 diabetes
- Most recent eGFR <20 ml/min/1.73 m2
- Prior kidney transplant
- Autosomal dominant polycystic kidney disease (ADPKD)
- Active pregnancy or plans for conception within 1 year
Where it is running
- University of Alabama — Birmingham, Alabama, United States (enrolling)
- Orlando Health — St. Petersburg, Florida, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Essentia Institute of Rural Health — Duluth, Minnesota, United States (enrolling)
- Duke University — Durham, North Carolina, United States (enrolling)
- Houston Methodist — Houston, Texas, United States (enrolling)
- Baylor Scott & White — Temple, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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