Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function

Enrolling by invitation · Not applicable

Conditions studied: INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied

In brief

The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.

Key facts

Study ID

NCT06906536

Run by

University of Colorado, Boulder

People needed

100

Starts

2024-03-01

Expected to finish

2026-08-01

Last updated by the study team

2025-04-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 75 years old (the latter to reduce likelihood of heart disease)
• Medically stable with medical clearance from physician to participate
• Motor-incomplete spinal cord injuries at or below C2 and at or above L5
• AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.)
• More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery
• Ability to advance one step overground with or without assistive devices;

You may not qualify if…

• Severe concurrent illness or pain
• Recurrent autonomic dysreflexia
• History of cardiovascular/pulmonary complications
• Concurrent physical therapy
• Pregnant at time of enrollment or planning to become pregnant
• Untreated painful musculoskeletal dysfunction, fracture or pressure sore
• History of seizures or epilepsy
• Recurring headaches
• Concussion within the last six months
• Depression or manic disorder
• Metal implants in the head, or pacemaker
• Aversion to needles

Where it is running

• Andrew Tan — Boulder, Colorado, United States

Full record on ClinicalTrials.gov

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