Molecular-Based Selection of Patients with Head and Neck Squamous Cell Carcinoma: Biomarker Analysis

Recruiting now

Conditions studied: Head and Neck Squamous Cell Carcinoma, Locally Advanced Stage

In brief

This is an observational, prospective study enrolling patients who meet the inclusion criteria and provide consent for the use of biopsy samples collected as part of standard clinical practice. The analysis will focus on the following biomarkers: TP53, P16, Cyclin D1, EGFR, Akt, PDL-1, and ERCC1. These biomarkers will be examined in both observation groups.

Key facts

Study ID

NCT06905145

Run by

National Cancer Institute, Naples

People needed

128

Starts

2024-05-03

Expected to finish

2032-05-01

Last updated by the study team

2025-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged > 18 years
• Written informed consent approved by the competent Independent Ethics Committee
• Histopathological diagnosis of squamous cell carcinoma of the head and neck region originating from one of the following organs or structures: Oral cavity, oropharynx, larynx, hypopharynx
• Locally advanced stage: from T1N1M0 to T4N3M0
• Availability of a tissue sample from a biopsy performed according to clinical practice guidelines.

You may not qualify if…

• Recurrent/metastatic disease
• Presence of a synchronous second tumor

Where it is running

• Istituto Nazionale Tumori | "Fondazione Pascale" — Naples, Italy (enrolling)

Full record on ClinicalTrials.gov

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