Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial

Recruiting now · Phase 2/Phase 3

Conditions studied: Spinal Cord Injury Cervical

In brief

This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life. It will compare transcutaneous spinal cord stimulation and paired corticospinal-motoneuronal stimulation, both combined with rehabilitation. Using a crossover design, participants will receive each therapy for two months, with a one-month washout period in between. Safety, effectiveness, and patient-reported outcomes like daily living ability and quality of life will be assessed, alongside changes in neural excitability. The results of this study may enable us to tailor treatments to individual needs, promoting personalized care and improved outcomes.

Key facts

Study ID

NCT06903416

Run by

University of Alberta

People needed

10

Starts

2025-05-07

Expected to finish

2030-03-31

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cervical (C2-C8) level SCI
• > 9 months post-injury
• Traumatic SCI
• AIS A-D
• Stable dose of anti-spasmodics

You may not qualify if…

• individuals with injury to the nervous system other than to the spinal cord
• pregnant

Where it is running

• Glenrose Rehabilitation Hospital — Edmonton, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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