Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty
Recruiting now · Phase 4
Conditions studied: Sleep, Knee Osteoarthritis
In brief
The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery
Key facts
- Study ID
- NCT06902285
- Run by
- University of Miami
- People needed
- 64
- Starts
- 2025-04-21
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients undergoing primary total knee or hip arthroplasty at the University of Miami Hospital
- Patients > 18 years of age
- Subjects must be capable of providing informed consent
- English or Spanish-speaking
You may not qualify if…
- Previous total joint arthroplasty at the surgical site
- History of sleeping disorders, including narcolepsy, sleep apnea, insomnia, parasomnias, and restless leg syndrome.
- History of Complex Regional Pain Syndrome in ipsilateral extremity
- History of demyelinating disorder or neurologic deficit in the affected extremity
- History of psychiatric disorders that could impact sleep, such as untreated depression, bipolar disorder, or schizophrenia.
- Participants taking medications known to cause significant sedation or insomnia.
- Pregnant or breastfeeding
- Being treated for a diagnosis other than primary osteoarthritis (e.g. pelvic/femur fracture)
- Patients with known substance use disorder within 6 months of surgery
- Liver Failure, via clinical diagnosis or international normalized ratio greater than 1.5 or Prothrombin time greater than 40
- Chronic Kidney Disease or glomerular filtration rate less than 30 mL/min
Where it is running
- University of Miami Hospital — Miami, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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