To Evaluate Mucosal and Systematic Immune Response to Acute Respiratory Tract Infections of South African Children

Recruiting now

Conditions studied: Respiratory Tract Infections (RTI), Mucosal Immunity

In brief

The goal of this observational study is to answer a few questions about respiratory tract infections in South African children: 1. How do children with COVID-19 and other respiratory (chest, throat, ear or nose) germs show symptoms? What signs should be looked for, and which children are more likely to get seriously ill? Are there any new germs that haven't been discovered yet? Can immune cells in saliva predict which children will get more severe disease? 2. The body's immune response (soldier- cells) in blood and saliva (spit) will be studied. 3. What is the short-term effect of COVID-19 and other respiratory viruses/ germs on the breathing (lung function) of children? 4. What is the impact of respiratory germs on the quality of life in children and their families? The investigators aim to recruit a minimum of 250 children with respiratory pathogens.

Key facts

Study ID

NCT06902194

Run by

Desmond Tutu TB Centre

People needed

250

Starts

2024-10-23

Expected to finish

2025-11-01

Last updated by the study team

2025-03-30

Who can join

Age: any, up to 13. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children aged 0-13 years with acute respiratory tract infections presenting to Tygerberg Hospital (TBH) in Cape Town, South Africa, for routine care

You may not qualify if…

• Admitted for < 72 hours

Where it is running

• Desmond Tutu TB Centre, Tygerberg Hospital — Cape Town, Western Cape, South Africa (enrolling)
• Desmond Tutu TB Centre — Cape Town, Western Cape, South Africa (enrolling)

Full record on ClinicalTrials.gov

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