Graded Exercise Hypoxia Testing

Running, not enrolling

Conditions studied: Hypoxia

In brief

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Key facts

Study ID

NCT06901284

Run by

Mayo Clinic

People needed

50

Starts

2025-04-15

Expected to finish

2028-04-24

Last updated by the study team

2026-01-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Physically active (≥150 minutes of moderate physical activity per week)

You may not qualify if…

• Contraindications to exercise testing
• Currently pregnant
• Musculoskeletal or metabolic disease
• Allergies to lidocaine
• Body-mass index ≤18 or ≥35 kg·m-2
• Pacemaker
• No confounding cardiorespiratory disease
• Persistent tobacco use (>15 pack years)

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States
• St. Mary's Hospital — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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