Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Running, not enrolling

Conditions studied: ACS (Acute Coronary Syndrome)

In brief

The goal of this proposal is to improve the quality and value of care for patients with acute chest pain by investigating the potential impact of point-of-care (POC) high sensitivity cardiac troponin (hs-cTn) testing in the Emergency Department (ED) and exploring how best to integrate POC hs-cTnl into ED risk stratification workflows. The study hypothesizes that the Abbott i-STAT POC hs-cTnI assay will decrease time-to-result (TTR) and ED length of stay (LOS), while increasing ED revenue for patients with acute chest pain compared to a strategy of central laboratory hs-cTnI testing.

Key facts

Study ID

NCT06899776

Run by

Wake Forest University Health Sciences

People needed

600

Starts

2025-02-07

Expected to finish

2026-12-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to18 years
• Symptoms suggestive of acute coronary syndrome:
• Acute chest, epigastric, neck, jaw or arm pain or discomfort or pressure without apparent non-cardiac source
• Shortness of breath, nausea, vomiting, fatigue/malaise, or
• Other equivalent discomfort suggestive of an myocardial infarction (MI)
• Electrocardiogram (ECG) ordered as part of standard of care
• At least one troponin collected as standard of care
• Study specific blood sample collected within ± 5 minutes of clinical draw

You may not qualify if…

• ST-segment elevation myocardial infarction (STEMI) Activation
• Unstable vitals signs: symptomatic hypotension at the time of enrollment (systolic < 90 mm Hg), tachycardia (HR>120), bradycardia (HR<40), and hypoxemia (<90% pulse-oximetry on room air or normal home oxygen flow rate)
• Central laboratory hs-cTn testing resulted or in process (>5 minutes) prior to study accrual
• Prior enrollment
• Terminal diagnosis with life expectancy less than 6 months

Where it is running

• Carolinas Medical Center — Charlotte, North Carolina, United States
• High Point Medical Center — High Point, North Carolina, United States
• Wake Forest School of Medicine — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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