Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma

Recruiting now · Phase 1

Conditions studied: Multiple Myeloma

In brief

Multiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the adverse events and change in disease activity of etentamig in combination with a cereblon E3 ligase modulatory drug (CELMoD) agent in adult participants with relapsed/refractory (R/R) multiple myeloma (MM). Adverse events and change in disease state will be assessed. Etentamig is an investigational drug being developed for the treatment of R/R MM. Study doctors put the participants in groups called treatment arms. Multiple doses of etentamig in combination with iberdomide will be explored. Each treatment arm receives a different dose of etentamig and iberdomide to determine a tolerable dose. Approximately 135 adult participants with R/R MM will be enrolled in the study in approximately 50 sites worldwide. In phase 1 participants will receive escalating intravenous (IV) etentamig in combination with oral iberdomide. In phase 2 participants will receive IV etentamig at one of two doses in combination with oral iberdomide, as part of the approximately 129 month study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and and monitoring of side effects.

Key facts

Study ID

NCT06896916

Run by

AbbVie

People needed

135

Starts

2025-08-07

Expected to finish

2036-03-01

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance of 0 or 1.
• Must have confirmed diagnosis of Relapsed/Refractory Multiple Myeloma (RRMM) after the participant's last treatment, as outlined in the protocol.
• All participants must have measurable diseases per central laboratory as outlined in protocol

You may not qualify if…

• Has received prior etentamig treatment.
• Prior exposure to BCMA-targeted therapy as noted in the protocol.
• Has received prior cereblon E3 ligase modulatory drug (CELMoD) (iberdomide or mezigdomide).

Where it is running

• Beverly Hills Cancer Center /ID# 266921 — Beverly Hills, California, United States (enrolling)
• Colorado Blood Cancer Institute /ID# 273751 — Denver, Colorado, United States (enrolling)
• Washington University /ID# 266972 — St Louis, Missouri, United States (enrolling)
• Rutgers Cancer Institute of New Jersey /ID# 266833 — New Brunswick, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Cancer Center - New York - York Avenue /ID# 270282 — New York, New York, United States (enrolling)
• University Of North Carolina Health Care - Hillsborough Campus /ID# 278230 — Hillsborough, North Carolina, United States (enrolling)
• Swedish Medical Center - Seattle /ID# 268052 — Seattle, Washington, United States (enrolling)
• Blacktown Hospital /ID# 265983 — Blacktown, New South Wales, Australia (enrolling)
• Wollongong Hospital /ID# 265625 — Wollongong, New South Wales, Australia (enrolling)
• The Alfred Hospital /ID# 265981 — Melbourne, Victoria, Australia (enrolling)
• Austin Hospital /ID# 265984 — Melbourne, Victoria, Australia (enrolling)
• Sir Charles Gairdner Hospital /ID# 265985 — Nedlands, Western Australia, Australia (enrolling)
• University Health Network_Princess Margaret Cancer Centre /ID# 275636 — Toronto, Ontario, Canada (enrolling)
• Jewish General Hospital /ID# 267574 — Montreal, Quebec, Canada (enrolling)
• Chu de Nice-Hopital Larchet Ii /Id# 266845 — Nice, Alpes-Maritimes, France (enrolling)
• Hôpital La Timone /ID# 267053 — Marseille, Bouches-du-Rhone, France (enrolling)
• Chu De Lille - Hopital Claude Huriez /ID# 270193 — Lille, Hauts-de-France, France (enrolling)
• Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau /ID# 267694 — Tours, Indre-et-Loire, France (enrolling)
• IUCT Oncopole /ID# 266391 — Toulouse, Occitanie, France (enrolling)
• National Cancer Center Hospital East /ID# 268343 — Kashiwa-shi, Chiba, Japan (enrolling)
• Kumamoto University Hospital /ID# 270530 — Kumamoto, Kumamoto, Japan (enrolling)
• Dokkyo Medical University Hospital /ID# 271648 — Mibu, Tochigi, Japan (enrolling)
• Nippon Medical School Hospital /ID# 270254 — Bunkyo-ku, Tokyo, Japan (enrolling)
• The Cancer Institute Hospital Of JFCR /ID# 268342 — Koto-ku, Tokyo, Japan (enrolling)
• Amsterdam UMC, Location VUmc /ID# 267670 — Amsterdam, North Holland, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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