Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

Recruiting now · Not applicable

Conditions studied: ANOCA - Angina With Non-obstructive Coronary Arteries, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)

In brief

This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.

Key facts

Study ID

NCT06896903

Run by

Baylor Research Institute

People needed

50

Starts

2025-05-21

Expected to finish

2027-06-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 or older
• Patient being evaluated for ANOCA or INOCA
• Clinical suspicion for angina
• Patient should be able to comply with the protocol.
• Provide written informed consent before study participation.

You may not qualify if…

• Existing coronary artery disease
• Previous percutaneous interventions within the coronaries
• Current use (within 48 hours) of long-acting nitrate therapies
• Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)
• Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
• Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.

Where it is running

• Baylor Scott & White The Heart Hospital - Plano — Plano, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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