Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?

Recruiting now

Conditions studied: Postbariatric Hypoglycemia

In brief

The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol. The main question it aims to answer is whether changes in cortisol contribute to the development of reactive hypoglycemia? 100 individuals who have previously undergone bariatric surgery, are planned to be included.

Key facts

Study ID

NCT06896682

Run by

Esbjerg Hospital - University Hospital of Southern Denmark

People needed

100

Starts

2025-07-08

Expected to finish

2026-12-31

Last updated by the study team

2026-03-13

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must have undergone one of the following bariatric procedures at least 12 months prior:
• Roux-en-Y gastric bypass
• Gastric sleeve

You may not qualify if…

• Pregnancy and breastfeeding
• Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration
• Use of corticosteroid medications, such as prednisolone
• Use of opiod-containing medication
• Use of medications containing estrogen, such as hormone therapy for menopause
• Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome
• Diabetes that does not require medical treatment
• Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment

Where it is running

• Esbjerg Hospital — Esbjerg, Denmark (enrolling)

Full record on ClinicalTrials.gov

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