Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity.

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Conditions studied: Human Neural Cells Functioning

In brief

Understanding the functioning of human neurons has always been a key element, especially with regard to the translation of the inputs they receive into actions that determine human behavior. However, the vast majority of studies have been performed in animal models due to the difficulty in maintaining neuronal functions ex vivo. Recently, techniques have been illustrated that allow us to obtain slices of brain tissue removed during neurosurgical interventions. The patch-clamp and HD-MEA (high density - microelectrodes array) techniques, used until now for animal samples, can allow us to study the functioning of the neural cells that make up these slices. Furthermore, the exploration of the functioning of the aforementioned cells in pathological conditions can open the field for further therapeutic perspectives.

Key facts

Study ID

NCT06896331

Run by

Fondazione IRCCS Policlinico San Matteo di Pavia

People needed

60

Starts

2024-09-17

Expected to finish

2027-09-01

Last updated by the study team

2025-03-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned.

You may not qualify if…

• patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned

Where it is running

• Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Pavia, Italy (enrolling)

Full record on ClinicalTrials.gov

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