Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Recruiting now · Phase 4

Conditions studied: Chronic Obstructive Pulmonary Disease (COPD)

In brief

The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days. Participants will randomized to receive treatment with either hydrocortisone or prednisolone.

Key facts

Study ID

NCT06892210

Run by

Copenhagen Respiratory Research

People needed

2000

Starts

2026-03-10

Expected to finish

2030-11-01

Last updated by the study team

2026-03-18

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥40 years
• Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44

You may not qualify if…

• All diagnoses that would merit treatment with a specific corticosteroid
• Pregnant or breastfeeding women
• Active tuberculosis or invasive fungal infection

Where it is running

• Bornholm Hospital — Rønne, Bornholm, Denmark (enrolling)
• Amager Hospital — Copenhagen, Copenhagen City, Denmark (enrolling)
• Bispebjerg Hospital — Copenhagen, Copenhagen City, Denmark (enrolling)
• Frederiksberg Hospital — Frederiksberg, Copenhagen City, Denmark (enrolling)
• Gentofte Hospital — Hellerup, Copenhagen City, Denmark (enrolling)
• Herlev Hospital — Herlev, Copnhagen Surroundings, Denmark (enrolling)
• Hvidovre Hospital — Hvidovre, Copnhagen Surroundings, Denmark (enrolling)
• Nordsjællands Hospital — Hillerød, North Zealand, Denmark (enrolling)
• Holbæk Sygehus — Holbæk, Region Sjælland, Denmark (enrolling)
• University Hospital of Region Zealand, Køge — Køge, Region Sjælland, Denmark (enrolling)
• Næstved Sygehus — Næstved, Region Sjælland, Denmark (enrolling)
• Ringsted Sygehus — Ringsted, Region Sjælland, Denmark (enrolling)
• University Hospital of Region Zealand, Roskilde — Roskilde, Region Sjælland, Denmark (enrolling)
• Slagelse Sygehus — Slagelse, Region Sjælland, Denmark (enrolling)

Full record on ClinicalTrials.gov

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