EEG-based Personalized Transcranial Magnetic Stimulation (eTMS) to Treat Post-Traumatic Stress Disorder

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Stress Disorder, Post Traumatic

In brief

This is a randomized, sham controlled study of the Electroencephalogram (EEG) based Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD). The recruitment goal is 110 participants who are United States Military veterans or first responders (e.g., firefighters, police, paramedics, etc.). The Study includes an EEG recording in order to determine the optimal treatment parameters for the eTMS system, followed by 15 in-office visits that take place over 21-28 total days. Two eTMS treatment sessions are administered during each office visit.

Key facts

Study ID

NCT06892028

Run by

Wave Neuroscience

People needed

110

Starts

2025-02-12

Expected to finish

2026-01-31

Last updated by the study team

2025-03-24

Who can join

Age: 22 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing and able to consent to participate in the study via signed Informed Consent
• Age 22 - 65 years
• Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS).
• Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit
• Veterans Administration PCL-5 cut point score of 31 or above
• Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel)

You may not qualify if…

• Uncontrolled medical, psychological or neurological condition
• Pregnant, or female unwilling to use effective birth control during the course of the trial
• Metal objects in the head
• Past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck
• Current participation in any interventional research protocol
• History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)
• History of stroke or intracranial lesion or increased intracranial pressure
• History of epilepsy of seizure
• Family history of epilepsy or seizure in 1st degree relative
• An elevated risk of suicide or violence to others

Where it is running

• Wright State University — Dayton, Ohio, United States (enrolling)
• D2 Human Performance Center — Pickerington, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.