Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
Recruiting now · Not applicable
Conditions studied: COPD, Emphysema
In brief
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea due to hyperinflation despite optimal medical treatment. The Apreo BREATHE Airway Scaffold is a permanent implant designed to tent open native airways. The study will include up to 250 participants at up to 25 study centers located in the United States and Europe. Study subjects will be followed for 3 years. The main questions it aims to answer are: Is it safe? Does it work?
Key facts
- Study ID
- NCT06891755
- Run by
- Apreo Health, Inc.
- People needed
- 250
- Starts
- 2025-07-15
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-04-24
Who can join
Age: 40 and older, up to 84. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
- Banner Health — Gilbert, Arizona, United States (enrolling)
- University of California at Davis — Sacramento, California, United States (enrolling)
- Mayo Clinic — Jacksonville, Florida, United States (enrolling)
- Orlando Health — Orlando, Florida, United States (enrolling)
- University of Chicago — Chicago, Illinois, United States (enrolling)
- OSF St Francis Medical Center — Peoria, Illinois, United States (enrolling)
- University of Kansas Medical Center Research Institute — Kansas City, Kansas, United States (enrolling)
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)
- The Ohio State University — Columbus, Ohio, United States (enrolling)
- Clinical Research Associates of Central Pennsylvania — DuBois, Pennsylvania, United States (enrolling)
- Temple University — Philadelphia, Pennsylvania, United States (enrolling)
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (enrolling)
- Houston Methodist/Primary Critical Care — Houston, Texas, United States (enrolling)
- Inova Health Care Services — Falls Church, Virginia, United States (enrolling)
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
- Karl Landsteiner Institute - Klink Floridsdorf — Vienna, Austria (enrolling)
- University Medical Center Groningen — Groningen, Netherlands (enrolling)
- St. Bartholomew's Hospital — London, United Kingdom (enrolling)
- Royal Brompton Hospital — London, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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