Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia

Recruiting now · Not applicable

Conditions studied: Zoster; Herpes, Trigeminal Neuralgia (Etiology)

In brief

To assess the 1-month effects and safety of esketamine combined PRF and standardized treatment to relieve pain in patients with acute/subacute zoster-related trigeminal neuralgia(ZRTN).

Key facts

Study ID

NCT06890897

Run by

Beijing Tiantan Hospital

People needed

174

Starts

2025-04-01

Expected to finish

2026-09-30

Last updated by the study team

2025-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >18 years;
• History of HZ within the last three months;
• Lesions located in the trigeminal nerve or its branches innervated regions；
• Numeric Rating Scale (NRS) pain score≥4 (NRS, 0 = no pain, 10= worst possible pain) with pharmacotherapy;
• Planned to perform CT-guided PRF treatment of the Gasserian ganglion .

You may not qualify if…

• Obstructive sleep apnoea syndrome;
• Those who receive other invasive treatments, such as spinal cord stimulation;
• A history of systemic immune diseases, organ transplantation, or cancers;
• A history of severe cardiopulmonary, hepatic or renal dysfunction;
• A history of schizophrenia, epilepsy, or myasthenia gravis, delirium;
• Comorbid hyperthyroidism or phaeochromocytoma;
• Recent history of drug abuse;
• Having contraindications to esketamine;
• Communication difficulties.
• Withdrawal criteria
• Lost to follow-up during the study;
• Not perform the planned operation;
• Receiving other treatment regimes during the study period;
• Not suitable for continuing the study for emerging severe comorbidities or special physiological changes during the study;
• Voluntary withdrawal from the study.

Where it is running

• Beijing Tiantan Hospital — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

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