Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS

Recruiting now

Conditions studied: PCOS, Hyperinsulinism, Hyperandrogenism, Metabolic Syndrome

In brief

The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance test (OGTT) c) the impact of potential treatment interventions in these markers.

Key facts

Study ID

NCT06889454

Run by

Attikon Hospital

People needed

120

Starts

2024-02-01

Expected to finish

2026-02-01

Last updated by the study team

2025-11-19

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age > 16 years old
• Diagonis of PCOS according to Rotterdam criteria: presence of two of the three of the following:
• Clinical or biochemical hyperandrogenism
• Anovulation or oligo-ovulation
• Polycystic ovarian morphology (PCOM)
• Absence of treatment for PCOS the last six months
• Patients who have the ability to understand and sign the consent form.

You may not qualify if…

• Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone [17-OHP]), Cushing syndrome, acromegaly
• Treatment with contraceptive or metformin
• Type 2 diabetes mellitus
• Treatment for diabetes
• Pregnancy
• Lactation
• Malignancy

Where it is running

• Attikon University General Hospital — Chaïdári, Greece (enrolling)

Full record on ClinicalTrials.gov

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