Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.

Recruiting now

Conditions studied: Hip Arthroplasty Replacement

In brief

Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume. The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.

Key facts

Study ID

NCT06888908

Run by

Copenhagen University Hospital, Hvidovre

People needed

25

Starts

2025-03-01

Expected to finish

2026-09-01

Last updated by the study team

2025-03-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for an elective total hip arthoplasty (THA) in a standardized fast track setting.
• Capable of participating in CO-rebreathing measurement
• Age ≥ 18 years
• Able to speak and understand Danish
• Has provided written informed consent.

You may not qualify if…

• Intraoperative blood loss exceeding 750 mL.
• Perioperative need for a blood transfusion.
• Confirmed or suspected coagulopathies.
• Factors that make CO-rebreathing measurement impossible.
• Known orthostatic intolerance.
• American Society of Anesthesiologists physical status (ASA) classification ≥ 4.

Where it is running

• Hvidovre University Hospital — Copenhagen, Denmark (enrolling)

Full record on ClinicalTrials.gov

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