Impact of Stress on Cardiovascular Events in Patients with Peripheral Arterial Disease

Recruiting now

Conditions studied: Peripheral Arterial Disease

In brief

Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Patients with peripheral arterial disease are at increased risk suffering from major adverse cardiac and limb events. Acute and chronic stress affect the cardiovascular system. Long-term negative stressors lead to cardiovascular diseases and can aggravate already existing cardiovascular diseases. However, current guidelines on cardiovascular disease prevention highlight stress as a cardiovascular risk factor there is a lack of consensus about the definition and measurement of stress. The aim of the proposed trial is to evaluate different stress measuring methods in patients with PAD depending on the occurrence of cardiovascular events.

Key facts

Study ID

NCT06887101

Run by

University Hospital, Essen

People needed

300

Starts

2023-04-21

Expected to finish

2026-12-31

Last updated by the study team

2025-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of lower extremity PAD based on:
• Limb bypass surgery or
• aorta-femoral bypass surgery or
• percutaneous transluminal angioplasty revascularization of the iliac or infrainguinal arteries or
• limb or foot amputation for arterial vascular disease or
• intermittent claudication and one or more of either an ankle brachial index (ABI) of less than 0.90 or a peripheral artery stenosis (≥50%) documented by angiography or duplex ultrasound or carotid revascularization or asymptomatic carotid artery stenosis of at least 50% diagnosed by duplex ultrasound or angiography

You may not qualify if…

• atrial fibrillation
• high premature ventricular contractions burden
• pacemaker with constant ventricular pacing
• antiarrhythmic drugs class I or III

Where it is running

• Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen — Essen, Germany (enrolling)

Full record on ClinicalTrials.gov

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