Sickle Cell, Pain and Mediterranean Diet

Completed · Not applicable

Conditions studied: Sickle Cell, Sickle Cell Disease, Sickle Cell Disease Without Crisis, Mediterranean Diet

In brief

The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.

Key facts

Study ID

NCT06886477

Run by

University of Illinois at Chicago

People needed

37

Starts

2025-05-01

Expected to finish

2026-07-09

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Sickle Cell Disease Diagnosis
• Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for > 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?")
• Ability to speak, read, write, and understand English
• A Mediterranean Eating Pattern for Americans (MEPA-III) score <13, indicating that they do not follow a Mediterranean diet.

You may not qualify if…

• Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks)
• History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome)
• History of Clostridium difficile infection in the preceding 12 weeks;
• Unable to agree to maintain physical activity at the current level for the duration of the study
• Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet
• Lack of access to a space to safely store and reheat food items
• Living in a facility that provides meals.
• Pregnancy or breastfeeding
• More than 7 in-patient hospital stays in the last year
• Currently receiving dialysis treatment

Where it is running

• University of Illinois Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.