Effect of Mannitol on Propofol Level

Recruiting now · Phase 4

Conditions studied: Mannitol Adverse Reaction

In brief

Group 1 will include 20 patients aged 18 years and over, American Society of Anesthesiologist (ASA) II-III class, who will undergo supratentorial tumor surgery, and Group 2 will include 20 patients who will undergo pituitary surgery without mannitol. Total intravenous anesthesia (TIVA) will be adjusted to propofol 4 µg/dl and remifentanil 2-4 µg/dl with target-controlled infusion pumps. In the mannitol group, 2.5 ml/kg (0.5 g/kg) will be given to all patients 20 minutes after induction and the mannitol infusion will be adjusted to be 10 minutes.In Group 2, mannitol will not be used and 2.5 ml/kg isotonic will be administered in 10 minutes. Both blood and urine samples will take for measurement to propofol levels.

Key facts

Study ID

NCT06884657

Run by

Cukurova University

People needed

40

Starts

2025-03-20

Expected to finish

2025-10-30

Last updated by the study team

2025-09-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologist (ASA) II participants
• supratentorial tumor surgery
• eligible for mannitol use
• eligible for Total intravenous anesthesia (TIVA)

You may not qualify if…

• American Society of Anesthesiologist (ASA) III and upper
• Chronic kidney failure
• sepsis
• multiorgan failure

Where it is running

• Çukurova University — Çukurova, Adana, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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