The Effects of Tyrosol and Creatine on Endurance, Strength, and Fatigue Resistance in Healthy Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Tyrosol, Creatine, Endurance Performance, Cognition

In brief

The purpose of this clinical trial is to look at tyrosol's effects on endurance, strength, and fatigue resistance in humans. Additionally, the combination of tyrosol and creatine monohydrate will also be looked at to determine if there is a cooperative effect from using both together. It will be conducted over a 4-week period to compare the effects of the following substances: 1) tyrosol, 2) a placebo (a look-alike substance that contains no drug), 3) creatine, and 4) a combination containing both creatine and tyrosol. Endurance, strength, and fatigue resistance will be compared between groups through repeated testing (described below). Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) cognitive testing; (3) full-body strength testing; (4) grip strength on both hands; (5) muscle power testing; (6 \& 7) Resting blood lactic acid testing followed by 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure, followed by another blood lactic acid reading; (8) a repeat of the muscle power testing; (9) a 1 mile time trial run completed as fast as possible. After the 4-week supplementation period (\~28-34 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will then repeat all physical testing procedures except tests 1, 6, 7, and 8, to determine physical recovery. Additionally, questionnaires for soreness and perceived recovery will also be completed at the beginning of Visit 2 and 3, and again on its own as the only testing event at 48 hours post-Visit 2 (visit 4).

Key facts

Study ID: NCT06883292
Run by: Applied Science & Performance Institute
People needed: 50
Starts: 2025-03-24
Expected to finish: 2025-08-30
Last updated by the study team: 2025-09-11

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Healthy males or females aged 18-50
Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
Estimated VO2 max equal to or greater than the 50th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
Able to read and write in English
During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
Females willing to share days menstrual cycle for testing purposes as shifts in hormone levels may, potentially, affect testing

You may not qualify if…

Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
Recent musculoskeletal injury (<3-months)
Recent orthopaedic surgery (<12-months)
History or current malignancy
Previous gastrointestinal surgery within the past 12 months
Regular smoker
Regular drinker (>14 drinks per week)
Current use (within the past 4 weeks) of creatine supplements
Current use (within past 3 months) of Tyrosol supplementation
Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)
Female subjects who do not test negative on a urine pregnancy test or are lactating.

Where it is running

Applied Science & Performance Institute — Tampa, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.