Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application
Recruiting now
Conditions studied: Glioma
In brief
Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.
Key facts
- Study ID
- NCT06883214
- Run by
- Regina Elena Cancer Institute
- People needed
- 10
- Starts
- 2023-01-17
- Expected to finish
- 2027-01-17
- Last updated by the study team
- 2026-06-05
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- histological diagnosis of glioma;
- no concomitant primary tumor;
- no metastatic disease;
- availability of surgical material/tissue;
- written informed consent.
You may not qualify if…
- histological diagnosis of non-glial tumor;
- patients with concomitant other solid tumors;
- metastatic disease;
- no surgical material/tissue available;
- HIV seropositivity.
Where it is running
- "Regina Elena" National Cancer Institute — Rome, Rome, Italy (enrolling)
Full record on ClinicalTrials.gov
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