Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis

Recruiting now · Early Phase 1

Conditions studied: Sepsis

In brief

The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.

Key facts

Study ID

NCT06882811

Run by

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

People needed

180

Starts

2025-05-22

Expected to finish

2027-12-31

Last updated by the study team

2025-05-25

Who can join

Age: any, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 0-65 years old, diagnosed with sepsis
• Clinical diagnosis of sepsis (based on Sepsis 3.0 International Guidelines)
• Confirmed or suspected infection

You may not qualify if…

• Violation of medical ethics
• Significant confounding factors likely to bias study outcomes
• Poor adherence to the study protocol
• Concurrent participation in other clinical trials
• Specific medical conditions:
• History of chronic enteritis, neuropsychiatric disorders, or transplantation (bone marrow, lung, liver, pancreas, or small intestine)
• Severe primary diseases affecting survival (e.g., life-limiting hepatic, renal, or endocrine disorders) or psychiatric disorders
• History of hypersensitivity or severe adverse reactions to biological products
• Imminent terminal status (e.g., septic shock, life expectancy <7 days)
• Foreseeable risk of medical errors or disputes during hospitalization
• Active drug-resistant infections
• History of malignancy at screening
• Pregnancy, lactation, or plans for pregnancy within the next year

Where it is running

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University — Chongqing, Chongqing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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