Phenotypic and Etiological Characterization of Susac Syndrome

Recruiting now

Conditions studied: Susac Syndrome

In brief

SUSAC's Syndrome (SS) is characterized by the clinical triad of encephalopathy, hearing loss, and retinal artery branch occlusions. Since the first description of SS in 1979, hundreds of patients with SS, mostly young women, have been reported. However, comprehensive epidemiological, clinical and etiological features of SS have never been specifically addressed so far.

Key facts

Study ID

NCT06881368

Run by

Assistance Publique - Hôpitaux de Paris

People needed

180

Starts

2025-07-01

Expected to finish

2045-02-15

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient over 18 years of age
• Patient presenting with at least two of the signs of the clinical triad: encephalopathy, cochlear damage authenticated by an audiogram (uni- or bilateral, predominantly in the middle or low frequencies), retinal artery occlusion assessed by fundoscopy or fluorescein retinal angiography.

You may not qualify if…

• Patient having been individually informed and objecting to the use of his/her data
• Patient under legal protection (guardianship or curatorship)
• Differential diagnosis established: multiple sclerosis, mitochondriopathy, CADASIL, primary tumour of the central nervous system, Lyme disease.

Where it is running

• Hôpital Bichat — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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