The Locus Coeruleus, Norepinephrine and Cognitive Aging

Running, not enrolling · Not applicable

Conditions studied: Alzheimer Disease

In brief

The locus coeruleus (LC) has recently been identified as one of the earliest sites of damage in AD with pathological lesions appearing as early as the mid-20s. In this study, the investigators use a variety of techniques including structural MRI, functional MRI, pupillometry, and transcutaneous vagus nerve stimulation to assess the health of the LC and its relation to easily measurable peripheral variables.

Key facts

Study ID

NCT06880510

Run by

Cornell University

People needed

150

Starts

2025-06-01

Expected to finish

2026-07-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18+ years of age
• Able to speak and understand English
• Hearing and vision correctable to normal or near-normal
• Willing and able to use a touchscreen
• Willing and able to use a keyboard and mouse
• Willing and able to undergo a MRI scan at the Cornell MRI Facility lasting approximately 90 minutes.

You may not qualify if…

• Moderate or severe brain injury
• Serious neurological disorders such as epilepsy
• Recent concussion
• Colorblindness
• Use of street drugs
• Cardiac arrhythmias

Where it is running

• Cornell University — Ithaca, New York, United States

Full record on ClinicalTrials.gov

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