Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth (iCARE) Plus Effectiveness/Implementation Hybrid Study

Recruiting now · Not applicable

Conditions studied: Adolescent HIV Infection

In brief

Two combination interventions (HIV Case Finding Intervention and HIV Treatment Intervention), each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials among youth aged 15-24 in Nigeria.

Key facts

Study ID

NCT06880224

Run by

Northwestern University

People needed

500

Starts

2025-02-01

Expected to finish

2028-08-31

Last updated by the study team

2026-04-08

Who can join

Age: 15 and older, up to 24. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• HIV Case Finding Intervention:
• Aged 15 to 24
• Male birth sex of any current gender identity
• Understand basic English, Yoruba, Hausa, Igbo or Pidgin English For the PrEP component, must also be HIV-negative
• HIV Treatment Intervention:
• Aged 15 to 24
• HIV seropositive
• Initiating ART for the first time at a Clinical Research Performance Site (CRPS) clinic or satellite clinic
• Understand basic English, Yoruba, Hausa, Igbo or Pidgin English
• Intention to remain a CRPS patient during follow-up

You may not qualify if…

• Unable to provide consent
• No parental permission if aged 15 and not emancipated

Where it is running

• University of Uyo Teaching Hospital — Uyo, Akwa Ibom State, Nigeria (enrolling)
• Federal Medical Center — Makurdi, Benue State, Nigeria (enrolling)
• Taraba State Specialist Hospital — Jalingo, Taraba State, Nigeria (enrolling)
• University of Nigeria Teaching Hospital — Enugu, Nigeria (enrolling)
• Aminu Kano Teaching Hospital — Kano, Nigeria (enrolling)
• Lagos University Teaching Hospital — Lagos, Nigeria (enrolling)

Full record on ClinicalTrials.gov

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