Retrospective Evaluation of Minimally-Invasive Surgical Strategies in Ovarian Neoplasms (REMISSION Study)

Recruiting now

Conditions studied: Early-stage Epithelial Ovarian Cancer

In brief

This observational study aims to evaluate the outcomes of patients with early-stage epithelial ovarian cancer who are treated with minimally invasive surgery (such as laparoscopic or robotic surgery). Specifically, the study will look at: 1. Post-Surgery Complications * What is the rate of complications within 30 days after surgery? * How often do patients require readmission to the hospital, re-operation, or conversion to open surgery? 2. Cancer Outcomes * What is the rate of cancer upstaging (when the cancer spreads to a more advanced stage during surgery for example because of an intra-operative ovarian cyst rupture)? * What are the overall survival and disease-free survival rates for patients treated with minimally invasive surgery? Researchers will compare two groups of patients: Group 1: Patients with early-stage ovarian cancer treated with minimally invasive surgery. Group 2: Patients with early-stage ovarian cancer treated with open surgery. The goal is to see if there are any differences in post-surgery complications, recovery, and cancer outcomes between the two groups. Fertility-Sparing Treatment: The study will also compare patients who are undergoing fertility-sparing treatments for early-stage ovarian cancer. Two subgroups will be looked at: * Patients receiving fertility-sparing surgery through a minimally invasive procedure. * Patients receiving fertility-sparing surgery through an open surgery. The same outcomes (complications, survival, etc.) will be assessed and compared between these two groups as well.

Key facts

Study ID

NCT06879730

Run by

Jvan Casarin, MD PhD

People needed

1500

Starts

2024-05-15

Expected to finish

2027-10-01

Last updated by the study team

2025-03-17

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients with apparent early-stage epithelial ovarian cancer at preoperative evaluation
• Patients who underwent surgery between January 2014 and December 2023
• Patients who underwent open or minimally invasive surgical staging (Laparoscopic or Robotic-assisted approach) or restaging procedure
• Patients with final pathology report of Epithelial Ovarian Cancer

You may not qualify if…

• Patients who have not performed a complete surgical staging
• Patients who underwent neoadjuvant chemotherapy
• Patients with invasive synchronous tumor
• Patients with no informed consent
• Patients with ASA class score of 4 or 5

Where it is running

• Ospedale Filippo del Ponte — Varese, Varese, Italy (enrolling)

Full record on ClinicalTrials.gov

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