Postprandial Metabolome and Metabolic Flexibility
Recruiting now · Not applicable
Conditions studied: Fasting, Postprandial Hyperglycemia, Lipid Metabolism Disorders, Glucose Metabolism Disorders, Insulin Sensitivity
In brief
Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of obesity, metabolic syndrome, insulin resistance, and type 2 diabetes. Considering that humans spend most of their awakening hours in a postprandial (PP) state, an organism's metabolic flexibility (MF) to respond to a standardized meal's consumption would provide information on the individual's metabolic health. The PP response to glucose following an oral glucose tolerance test or consumption of a high-carbohydrate meal is well described; however, few studies assess the FM and PP metabolome using mixed meals with different macronutrients. The investigators address how metabolic flexibility and metabolome change after consuming standardized meals with different macronutrient ratios. Data collection includes clinical and diet information, indirect calorimetry, and capillary blood sampling during fasting and after consumption of standardized meals. Samples are collected weekly for one month. The data will determine the metabolic flexibility and metabolome after consuming standardized meals with different macronutrient ratios.
Key facts
- Study ID
- NCT06878781
- Run by
- Instituto Nacional de Medicina Genomica
- People needed
- 300
- Starts
- 2024-01-08
- Expected to finish
- 2026-12-18
- Last updated by the study team
- 2025-03-17
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- be over 18 years of age and under 30 years of age;
- without active drug addictions: smoking, alcoholism, and/or drug addiction;
- in female subjects: regular menstrual cycles;
- give written consent for their inclusion in the study.
You may not qualify if…
- subjects with any pathology that requires medication or special treatment, such as type 2 diabetes mellitus, high blood pressure, dyslipidemia, polycystic ovary syn-drome, autoimmune, thyroid, kidney, neurological diseases, and cancer;
- pregnant or lactating women;
- subjects with problems with chewing, salivation, and swallowing.
- Elimination criteria:
- subjects who only have samples (blood and calorimetry) from one study period (fasting or postprandial);
- subjects who only have samples (blood and calorimetry) of a metabolic challenge;
- subjects who have an infection at the scheduled appointment;
- subjects who withdraw their informed consent
Where it is running
- Berenice Palacios-Gonzalez — Mexico City, Mexico (enrolling)
Full record on ClinicalTrials.gov
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