Reducing Risk of Stroke and DementIa In patientS With COVert cERebrovascular Disease

Starting soon

Conditions studied: Covert Cerebrovascular Disease

In brief

The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD.

Key facts

Study ID

NCT06878430

Run by

University of Edinburgh

People needed

100

Starts

2026-08-01

Expected to finish

2027-06-01

Last updated by the study team

2026-06-16

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• People who, at the time the letter is prepared or are identified by a clinician
• Age ≥ 65 years
• Have no known history of:
• Stroke or TIA
• Dementia
• Parkinson's disease
• Multiple sclerosis
• Metastatic cancer (or non-meningioma brain tumour).
• A CT or MRI scan report ≤5 years before study start date with of one or more of:
• Cerebral small vessel disease
• Deep old ischaemic stroke
• Cortical old ischaemic stroke

You may not qualify if…

• Text of brain scan report unreadable
• Do not consent to take part in study procedures
• Unable to consent
• Unable to communicate by email, letter or telephone through language, speech disability or lack of address
• Unlikely to survive one year past enrolment in judgement of the study investigator

Full record on ClinicalTrials.gov

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