Longitudinal Study to Investigate Different Transcranial Electrical Stimulation

Recruiting now · Not applicable

Conditions studied: Dementia; Degenerative, Dementia Mixed

In brief

This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of 4 weeks, everyday (Monday to Friday). The study design is a longitudinal study design in which participants receive different tES randomly ordered. Treatments occur for 4 weeks, then 12 weeks of no treatment (wash-out period), repeated for each tES treatment type. Participants have the option of having their choice of music in the background while they perform cognitive exercises.

Key facts

Study ID

NCT06877312

Run by

University of Manitoba

People needed

200

Starts

2024-10-09

Expected to finish

2033-12-31

Last updated by the study team

2025-12-04

Who can join

Age: 50 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ability to read, write and speak English fluently
• MoCA score between 5 and 24

You may not qualify if…

• Being diagnosed with Parkinson's disease, Parkinsonian dementia, Huntington disease, speech significant aphasia and intellectual disability, major depression/anxiety, bipolar disorder, schizophrenia or any other major mood disorder.
• Having a history of epileptic seizures or epilepsy
• Inability to adequately communicate in English
• Impaired vision or hearing severe enough to impair performance in cognitive tests
• Current substance abuse disorder
• Currently participating in another therapeutic study for dementia
• Plan to change the medication during any treatment period (5 weeks including the pre-post assessments)

Where it is running

• Riverview Health Centre — Winnipeg, Manitoba, Canada (enrolling)

Full record on ClinicalTrials.gov

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