MItral Regurgitation Risk Assessment and CLinical modElling

Recruiting now

Conditions studied: Mitral Insufficiency, Mitral Regurgitation (MR)

In brief

Mitral regurgitation (MR) is a common valvular heart disease worldwide, and untreated severe MR is associated with an elevated risk of heart failure and mortality. According to causes, MR could be divided into primary or secondary MR. The risk factors of mortality or heart failure hospitalization in different types of MR patients are under intensive investigation. MItral Regurgitation risk Assessment and CLinical modElling (MIRACLE) study is a prospective cohort study including adult patients diagnosed with ≥ moderate MR during hospitalization. Comprehensive echocardiographic examination was conducted at baseline evaluating valvular heart disease severity, atrial and ventricular systolic/diastolic function, pulmonary artery systolic pressure (PASP), etc. We aim to evaluate the prognostic risk factors of patients with MR and construct a prognostic clinical model to guide clinical decision-making.

Key facts

Study ID

NCT06876883

Run by

Sun Yat-sen University

People needed

2000

Starts

2016-06-15

Expected to finish

2030-06-15

Last updated by the study team

2025-09-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients diagnosed with ≥ moderate mitral regurgitation during hospitalization.
• Aged over 18 yrs.

You may not qualify if…

• Patients unable to provide written consent.

Where it is running

• The First Affiliated Hospital of Sun Yat-sen Univerity — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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