Regional Lymph Node Metastasis and Survival Outcomes in Advanced HCC
Recruiting now
Conditions studied: Hepatocellular Carcinoma (HCC)
In brief
Tumor-draining lymph nodes play an important role in anti-tumor immune responses. In patients with hepatocellular carcinoma (HCC), however, the relationship between regional lymph node metastasis (LNM) and immunotherapy-based efficacy is unclear. This study aimed to evaluate whether extrahepatic LNM is associated with worse survival outcomes as compared to other metastatic sites in patients with advanced HCC.
Key facts
- Study ID
- NCT06876753
- Run by
- Zhongda Hospital
- People needed
- 300
- Starts
- 2018-06-01
- Expected to finish
- 2025-07-01
- Last updated by the study team
- 2025-03-14
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Has a diagnosis of HCC confirmed by radiology, histology, or cytology;
- Barcelona Clinic Liver Cancer (BCLC) stage C with the presence of extrahepatic spread;
- Has not received any previous systemic therapy for HCC (including chemotherapy, molecularly targeted therapy, immunotherapy);
- Both PD-1/PD-L1 inhibitors and anti-angiogenesis drugs patients received only include marketed drugs but are not limited to HCC approval;
- TACE was performed after the first PD-1/PD-L1 inhibitor/anti-angiogenic drug treatment or before treatment (within 3 months);
- Received at least 1 cycle of PD-1/PD-L1 inhibitor/anti-angiogenic drug combination therapy after TACE treatment;
- Has repeated measurable intrahepatic lesions;
You may not qualify if…
- Cholangiocarcinoma, fibrolamellar, sarcomatoid hepatocellular carcinoma, and mixed hepatocellular/cholangiocarcinoma subtypes(confirmed by histology, or pathology) are not eligible;
- Unable to meet criteria of combination timeframe described above;
- Child-Pugh C or PS > 2 or Severe hepatic encephalopathy
Where it is running
- Zhongda Hospital — Nanjing, Jiangsu, China (enrolling)
- Zhongda Hospital — Nanjing, Jiangsu, China
Full record on ClinicalTrials.gov
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