Identification of B Regulatory Cells by Flow Cytometry

Starting soon

Conditions studied: Pollen Allergy, Venom Allergy

In brief

The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients who are receiving routine allergen immunotherapy treatment. The primary question this study aims to answer is; 1). Are changes in blood B-regulatory cells associated with successful allergen immunotherapy treatment, and therefore do these changes suggest patients have developed a suitable level of allergen tolerance and reduction in their allergic symptoms upon re-exposure to the causal allergen. Patients will also be asked to complete quality of life questionnaire periodically throughout the study to determine if there are associations between variation in B-regulatory cell populations in blood and allergic symptoms experienced.

Key facts

Study ID

NCT06876506

Run by

Hull University Teaching Hospitals NHS Trust

People needed

80

Starts

2026-08-01

Expected to finish

2027-09-30

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Patients under the age of 18 years
• Samples from patients with IgE-mediated allergic disease, treated or untreated, specific to allergens other than pollens, house dust mite and insect venom
• Participants who are pregnant
• Participants who cannot adequately understand verbal and / or written explanations given in English

Where it is running

• Hull Teaching Hospital NHS Trust — Hull, East Yorkshire, United Kingdom

Full record on ClinicalTrials.gov

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