Long-term Longitudinal Imaging of Presynaptic Terminals in PD

Recruiting now · Not applicable

Conditions studied: Parkinson Disease

In brief

AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD. STUDY DESIGN: The investigators will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinical assessment of motor and non-motor symptoms (including cognitive testing), as well as 11C-UCB-J PET-CT (targeting synaptic density marker SV2A), 18F-FE-PE2I PET-CT (targeting DAT) and brain MRI.

Key facts

Study ID

NCT06875765

Run by

Universitaire Ziekenhuizen KU Leuven

People needed

35

Starts

2025-07-16

Expected to finish

2027-12-01

Last updated by the study team

2025-07-29

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participation in study S61477 (NCT04243304)

You may not qualify if…

• Neuropsychiatric diseases (unrelated to PD for PD patients)
• Major internal medical diseases
• History of alcohol or drug abuse
• Relevant abnormalities on MR brain
• Contraindications for MR
• Pregnancy or breastfeeding
• Previous participation in other research studies involving ionizing radiation with > 1 mSv over past 12 months.

Where it is running

• UZ Leuven — Leuven, Belgium (enrolling)

Full record on ClinicalTrials.gov

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