Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder

Recruiting now

Conditions studied: Temporomandibular Joint Disorder

In brief

t is recognized that cortisol, a hormone produced by the adrenal glands, is a marker that is elevated in patients with psychological disorders, particularly anxiety. On the other hand, Temporomandibular Disorders (TMD) are a condition with a multifactorial etiology, in which emotional disturbances play a crucial role. Therefore, the aim of this study is to evaluate whether patients with TMD have higher levels of salivary cortisol compared to the general population. Initially, an assessment will be conducted using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol to determine whether the patient suffer of any kind of Temporomandibular Disorder. Based on the results, individuals will be classified into two groups: the study group, consisting of patients with TMD, and the control group, composed of individuals without the disorder. Those who agree to participate will be required to sign an informed consent form. Subsequently, a saliva sample will be collected for analysis.

Key facts

Study ID

NCT06874868

Run by

University of Coimbra

People needed

50

Starts

2024-09-15

Expected to finish

2025-05-30

Last updated by the study team

2025-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients who attend the dental clinic of the Faculty of Medicine of University of Coimbra

You may not qualify if…

• Pregnant women, minors and non-autonomous individuals

Where it is running

• Faculty of Medicine of University of Coimbra — Coimbra, Coimbra District, Portugal (enrolling)

Full record on ClinicalTrials.gov

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