Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback

Recruiting now · Not applicable

Conditions studied: Tourette Syndrome, Tics, Tourette Syndrome in Adolescence

In brief

The goal of this clinical trial is to compare the effectiveness of CoPs therapy with or without the therapeutic component of biofeedback in treating tics in Tourette Syndrome with emerging young adults. Hypotheses: 1. The CoPs+Biofeedback treatment will improve the severity of tics (YGTSS) and the Clinical Global Impression, surpassing the clinical significance threshold of CoPs treatment alone. 2. We expect that the identified variables (psychosocial, neurocognitive, biological) will predict the improvement of tics. Researchers will compare if the biofeedback treatment will improve the severity of tics. * In the pre-test, participants will undergo two interviews, each lasting 3 hours. These interviews will assess (through a battery of tests) the severity of tics as well as the psychosocial, biological, and neurocognitive aspects of functioning. A general assessment of intelligence and executive functions will also be conducted. * They will next attend 10 to 12 therapy sessions, with or without biofeedback. (The biofeedback component is explained in more detail in the ''Study Design'' section). * The post-test follow-ups consist of two evaluations: one 3 months after the end of the treatment and the other 6 months after. The evaluation will be done using the same battery of tests as during the pre-test interview.

Key facts

Study ID

NCT06873841

Run by

Université du Québec a Montréal

People needed

150

Starts

2025-04-15

Expected to finish

2029-12-01

Last updated by the study team

2025-07-08

Who can join

Age: 14 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a diagnosis of TS or to experience bothersome tics;
• Be aged 14 to 21 years inclusive at the start of therapy.

You may not qualify if…

• Present a sensorimotor impairment;
• Have a diagnosis of intellectual disability (intelligence quotient below 75);
• Alcohol or drug abuse;
• A neurological issue (e.g., hemifacial spasms, Huntington's disease);
• Change medication one month or less before step 1 and up to step 4 (last measurement time) without informing a member of the research team;
• Simultaneously receive another intervention for tics (e.g., psychologist, massage therapist) without informing a research team member.

Where it is running

• Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Hôpital Rivières-des-Prairies — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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