Neuromodulation and fMRI in Neurodegenerative Diseases Study

Starting soon · Not applicable

Conditions studied: Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration

In brief

In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcranial alternating current stimulation (tACS) has been suggested as a promising, non-invasive, method of normalizing network connectivity and hence improving cognition, notably memory. This study will examine the efficacy of tACS at improving working memory performance in patients with neurodegeneration and its correlation to changes in network connectivity, based on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) imaging data.

Key facts

Study ID

NCT06873750

Run by

Sunnybrook Health Sciences Centre

People needed

30

Starts

2026-06-01

Expected to finish

2028-12-01

Last updated by the study team

2026-05-01

Who can join

Age: 25 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Be at least 25 years of age;
• Have no contraindications to MRI
• Have received 8 or more years of formal education
• Be fluent in English
• Cohort a. must be followed at Sunnybrook Health Sciences Center
• Cohort a:
• Have been diagnosed with a suspected neurodegenerative disorder or traumatic brain injury (TBI) with memory deficits impacting functional status
• In case of TBI, cognitive impairment has persisted at least three months post-injury
• Received score of 16 or lower on the Mini Mental State Examination (MMSE)
• Cohort b:
• Have no prior diagnosis of a neurodegenerative disorder or post-traumatic brain injury cognitive deficits
• Be experiencing healthy aging and be age and sex matched to Cohort a.

You may not qualify if…

• Have any contraindications to MRI
• Be pregnancy
• Have any major comorbid medical conditions (as determined by investigators - e.g., comorbid neurological diseases, uncontrolled hypertension or diabetes, malignancy) or major comorbid psychiatric conditions (as determined by investigators - e.g., schizophrenia or bipolar disorder)

Full record on ClinicalTrials.gov

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